Childhood, adolescents, and young adults (≤25 y) colorectal cancer: study of Anatolian Society of Medical Oncology
- PMID: 23337551
- DOI: 10.1097/MPH.0b013e31827e7f20
Childhood, adolescents, and young adults (≤25 y) colorectal cancer: study of Anatolian Society of Medical Oncology
Abstract
Purpose: To evaluate the clinicopathologic characteristics and treatment outcomes of young patients with colorectal cancer (CRC).
Methods: Between May 2003 and June 2010, 76 patients were found eligible for this retrospective study. Age, sex, presenting symptoms, patients with acute presentation, family history, presence of polyps, histologic features, localization and stage of the tumor, treatment outcomes, time and site of recurrence, sites of metastasis, and survival outcomes were recorded from the patient files.
Results: Seventy-six patients (55.3% male) with a median age of 23 years were evaluated. Patients were evaluated in 2 groups as follows: child-adolescent (0 to 19 y, n=20) and young adult (20 to 25 y, n=56). Sex and symptoms (abdominal pain and rectal bleeding) were significantly differed between the groups and acute presentation was close to statistical significance. Overall survival significantly increased in patients undergoing curative surgery (P<0.001). Other parameters affecting the survival was stage of disease (P=0.004). Response to palliative chemotherapy in metastatic patients (P=0.042) and postoperative adjuvant chemotherapy had a statistically significant survival advantage (P=0.028).
Conclusions: Diagnosis of CRC should not be excluded solely on the basis of age. CRC features in young-adult patients are more similar to adults compared with that of child-adolescent patients according to the symptoms and presentation. In patients with CRC in this age group, curative surgery, adjuvant chemotherapy, and palliative chemotherapy provide survival advantage.
Similar articles
-
Clinicopathologic Profile and Treatment Outcomes of Colorectal Cancer in Young Adults: A Multicenter Study From India.JCO Glob Oncol. 2024 May;10:e2300225. doi: 10.1200/GO.23.00225. JCO Glob Oncol. 2024. PMID: 38754051
-
Clinicopathologic and Prognostic Differences between Three Different Age Groups (Child/Adolescent, Young Adults, and Adults) of Colorectal Cancer Patients: A Multicentre Study.Oncol Res Treat. 2019;42(10):516-522. doi: 10.1159/000502120. Epub 2019 Aug 22. Oncol Res Treat. 2019. PMID: 31437835
-
Are Markers of Systemic Inflammation Good Prognostic Indicators in Colorectal Cancer?Clin Colorectal Cancer. 2017 Dec;16(4):264-274. doi: 10.1016/j.clcc.2017.03.015. Epub 2017 Mar 24. Clin Colorectal Cancer. 2017. PMID: 28412137 Review.
-
Colorectal cancer diagnosed during pregnancy: systematic review and treatment pathways.Eur J Gastroenterol Hepatol. 2017 Jul;29(7):743-753. doi: 10.1097/MEG.0000000000000863. Eur J Gastroenterol Hepatol. 2017. PMID: 28252463 Review.
-
Colorectal carcinoma in children.J Pediatr Surg. 1999 Oct;34(10):1499-504. doi: 10.1016/s0022-3468(99)90112-4. J Pediatr Surg. 1999. PMID: 10549756
Cited by
-
Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer: A Systematic Review and Meta-Analysis.JAMA Netw Open. 2024 May 1;7(5):e2413157. doi: 10.1001/jamanetworkopen.2024.13157. JAMA Netw Open. 2024. PMID: 38787555 Free PMC article.
-
Colorectal Carcinoma in Childhood.JPGN Rep. 2020 Dec 17;2(1):e039. doi: 10.1097/PG9.0000000000000039. eCollection 2021 Feb. JPGN Rep. 2020. PMID: 37206941 Free PMC article. No abstract available.
-
Clinicopathologic and prognostic factors for colorectal cancer in children and adolescents: a population-based study.Int J Colorectal Dis. 2023 Feb 11;38(1):35. doi: 10.1007/s00384-023-04343-7. Int J Colorectal Dis. 2023. PMID: 36773067
-
miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT.Oncol Rep. 2023 Mar;49(3):50. doi: 10.3892/or.2023.8487. Epub 2023 Jan 27. Oncol Rep. 2023. PMID: 36704851 Free PMC article.
-
Time to diagnosis and treatment in younger adults with colorectal cancer: A systematic review.PLoS One. 2022 Sep 12;17(9):e0273396. doi: 10.1371/journal.pone.0273396. eCollection 2022. PLoS One. 2022. PMID: 36094913 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical