Kyle C Grant

Oxford, England, United Kingdom Contact Info
7K followers 500+ connections

Join to view profile

About

As the founder of Oxwash, I am leading a mission to decarbonise the unsustainable and…

Activity

Join now to see all activity

Experience & Education

  • The Enhanced Games

View Kyle C’s full experience

See their title, tenure and more.

or

By clicking Continue to join or sign in, you agree to LinkedIn’s User Agreement, Privacy Policy, and Cookie Policy.

Publications

  • Role of Hfq in an animal-microbe symbiosis under simulated microgravity conditions

    International Journal of Astrobiology

    Microgravity has a profound impact on the physiology of pathogenic microbes, however, its
    effects on mutualistic microbes is relatively unknown. To examine the effects of microgravity on
    those beneficial microbes that associate with animal tissues, we used the symbiosis between the bobtail squid Euprymna scolopes and a luminescent bacterium, Vibrio fischeri as a model
    system. Specifically, we examined the role of Hfq, an RNA binding protein known to be an
    important global regulator…

    Microgravity has a profound impact on the physiology of pathogenic microbes, however, its
    effects on mutualistic microbes is relatively unknown. To examine the effects of microgravity on
    those beneficial microbes that associate with animal tissues, we used the symbiosis between the bobtail squid Euprymna scolopes and a luminescent bacterium, Vibrio fischeri as a model
    system. Specifically, we examined the role of Hfq, an RNA binding protein known to be an
    important global regulator under space flight conditions, in the squid-vibrio symbiosis under
    simulated microgravity. To mimic a reduced gravity environment, the symbiotic partners were
    co-incubated in high-aspect ratio rotating wall vessel bioreactors and examined at various stages
    of development. Results indicated that under simulated microgravity hfq expression was down
    regulated in V. fischeri. A mutant strain defective in hfq showed no colonization phenotype
    indicating that Hfq was not required to initiate the symbiosis with the host squid. However, the
    hfq mutant showed attenuated levels of apoptotic cell death, a key symbiosis phenotype, within
    the host light organ suggesting that Hfq does contribute to normal light organ morphogenesis.
    Results also indicated that simulated microgravity conditions accelerated the onset of cell death
    in wild type cells but not in the hfq mutant strains. These data suggest that Hfq plays an important role in the mutualism between V. fischeri and its animal host and that its expression can be negatively impacted by simulated microgravity conditions.

    See publication

Projects

Honors & Awards

  • Medical Research Council Studentship

    MRC

  • Gillian Powell Memorial Scholarship

    Cardiff University

  • The Cardiff Student Alumni Award

    Cardiff University

  • The Portsmouth Grammar School Travel Award

    The Portsmouth Grammar School

Organizations

  • Society of Biology

    Associate Member

    - Present

  • UK Space Biomedicine Association

    Member

    - Present

  • United Kingdom Students for the Exploration and Development of Space

    Outreach

    - Present

Recommendations received

2 people have recommended Kyle C

Join now to view

More activity by Kyle C

View Kyle C’s full profile

  • See who you know in common
  • Get introduced
  • Contact Kyle C directly
Join to view full profile

People also viewed

Explore collaborative articles

We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.

Explore More

Add new skills with these courses

See all courses