David Holman

Washington, District of Columbia, United States Contact Info
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About

I am a Director in Sterne Kessler's Biotechnology & Chemical Practice Group. My practice…

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Experience & Education

  • Sterne, Kessler, Goldstein & Fox

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Publications

  • The New USPTO Examiner Manual And 102(e) Prior Art

    Law360

    Recent Federal Circuit decisions have held that, for a published patent application to qualify as §102(e) prior art as of its provisional application filing date, the provisional application must (1) support the relied upon disclosures in the published application and (2) provide §112, first paragraph, support for the claims in the published application. Consistent with the Federal Circuit precedent, the Patent Trial and Appeal Board has applied this §102(e) analysis to both patents and…

    Recent Federal Circuit decisions have held that, for a published patent application to qualify as §102(e) prior art as of its provisional application filing date, the provisional application must (1) support the relied upon disclosures in the published application and (2) provide §112, first paragraph, support for the claims in the published application. Consistent with the Federal Circuit precedent, the Patent Trial and Appeal Board has applied this §102(e) analysis to both patents and published patent applications. The U.S. Patent and Trademark Office’s January 2018 updates to the Manual of Patent Examining Procedure, however, seem to provide guidance for examiners that is at odds with the Federal Circuit and PTAB precedent. This article discusses the history of the Wertheim doctrine, Dynamic Drinkware and other recent Federal Circuit decisions, how §102(e) prior art has been treated at the PTAB, and as-yet unanswered questions involving the Wertheim doctrine.

    See publication
  • Patent Office Litigation, Second Edition

    Thomson Reuters

    Authored by nearly 70 Sterne Kessler attorneys, who have handled over 600 of the nearly 6,000 proceedings before the Patent Trial and Appeal Board (PTAB). The treatise provides readers with fresh and comprehensive explorations of all aspects of contested patent proceedings before the US Patent & Trademark Office (USPTO), and the interplay with the Administrative Procedures Act (APA), US District Courts, US International Trade Commission (USITC), US Court of Appeals for the Federal Circuit…

    Authored by nearly 70 Sterne Kessler attorneys, who have handled over 600 of the nearly 6,000 proceedings before the Patent Trial and Appeal Board (PTAB). The treatise provides readers with fresh and comprehensive explorations of all aspects of contested patent proceedings before the US Patent & Trademark Office (USPTO), and the interplay with the Administrative Procedures Act (APA), US District Courts, US International Trade Commission (USITC), US Court of Appeals for the Federal Circuit (Federal Circuit), complex patent preparation and prosecution strategies before the USPTO, and patent enforcement in other jurisdictions, such as the European Union and the proposed Unified Patent Court.

    See publication
  • Inter Partes Reviews: The Effect of Estoppel

    World Intellectual Property Review

    Now that the inter partes review system is three years old, what effects have the estoppel provisions had on concurrent or subsequent district court litigation?

    See publication
  • Human Embryonic Stem Cell Research: Statutory Interpretation of the Dickey-Wicker Amendment and the Future of Biomedical Research

    Federal Courts Law Review

    2011 Fed. Cts. L. Rev. 4 (Student Works Issue)

  • Protection of nonhuman primates against two species of Ebola virus infection with a single complex adenovirus vector

    Clinical and Vaccine Immunology, Apr;17(4):572-81

    Other authors
    • WD Pratt
    • D Wang
    • DK Nichols
    • M Luo
    • J Wararatanadharm
    • JM Dye
    • JY Dong
  • A Complex Adenovirus Vectored Vaccine Against Rift Valley Fever Virus Protects Mice Against Lethal Infection in the Presence of Pre-existing Vector Immunity

    Clinical and Vaccine Immunology, Nov;16(11):1624-32

    Other authors
    • A Penn-Nicholson
    • D Wang
    • J Woraratanadharm
    • MK Harr
    • M Luo
    • EM Maher
    • MR Holbrook
    • JY Dong
  • A Tetravalent Dengue Vaccine Based on a Complex Adenovirus Vector Protects Monkeys Against All Four Serotypes of Dengue Viruses

    Journal of Virology, Jul;82(14):6927-34

    Other authors
    • K Raviprakash
    • D Ewing
    • K Block
    • J Woraratanadharm
    • D Wang
    • JY Dong
    • L Chen
    • K Porter
  • Acid ceramidase inhibition: a novel target for cancer therapy

    Frontiers in Bioscience, Jan 1;13:2293-8

    Additional authors: YA Hannun YA, S Rubinchik, Z Szulc, TE Keane, M Tavassoli, JS Norris JS.

    Other authors
    • X Liu
    • S Elojeimy
    • LS Turner
    • AE Mahdy
    • YH Zeidan
    • A Bielawska
    • J Bielawski
    • JY Dong
    • AM El-Zawahry
    • GW Guo
  • Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells

    Cancer Chemotherapy and Pharmacology, Feb;61(2):231-42

    Additional author: JS Norris

    Other authors
    • LS Turner
    • AL El-Zawahry
    • S Elojeimy
    • X Liu
    • J Bielawksa
    • Z Szulc
    • K Norris
    • YH Zeidan
    • YA Hannun
    • A Bielaskwa
  • Multi-antigen vaccines based on complex adenovirus vectors induce protective immune responses against H5N1 avian influenza viruses

    Vaccine, May 19;26(21):2627-39

    Other authors
    • D Wang
    • NU Raja
    • M Luo
    • KM Moore
    • J Woraratanadharm
    • N Mytle
    • JY Dong
  • Vaccine to confer to nonhuman primates complete protection against multistrain Ebola and Marburg virus infections

    Clinical and Vaccine Immunology, Mar;15(3):460-7

    Other authors
    • DL Swenson
    • D Wang
    • M Luo
    • KL Warfield
    • J Woraratanadharm
    • JY Dong
    • WD Pratt
  • Complex Adenovirus-mediated expression of C, PreM, E, and NS1 proteins of West Nile Virus induces both humoral and cellular immune responses

    Clinical and Vaccine Immunology, Sep;14(9):1117-26

    Other authors
    • J Schepp-Berglind
    • M Luo
    • D Wang
    • JA Wicker
    • NU Raja
    • BD Hoel
    • ADT Barrett
    • JY Dong
  • Expression of dengue virus type 1 and type 2 antigens from a single adenoviral vector induces bivalent humoral immune responses

    American Journal of Tropical Medicine and Hygiene, April 1;76(4): 743-51.

    Other authors
    • NU Raja
    • D Wang
    • K Raviprakash
    • LY Juompan
    • SB Deitz
    • M Luo
    • J Zhang
    • K Porter
    • JY Dong
  • Role of Acid Ceramidase in Resistance to FasL: Therapeutic Approaches Based on Acid Ceramidase Inhibitors and FasL Gene Therapy

    Molecular Therapy, Jul;15(7):1259-63

    Additional authors: Dong JY, Bielawska A, Hannun YA, Norris JS.

    Other authors
    • S Elojeimy
    • X Liu
    • JC McKillop
    • AM El-Zawahry
    • JY Cheng
    • WD Meacham
    • AE Mahdy
    • AF Saad
    • LS Turner
    • T Day
  • Two Complex, Adenovirus-Based Vaccines That Together Induce Immune Responses to All Four Dengue Virus Serotypes

    Clinical and Vaccine Immunology, 14(2):182-9

    Other authors
    • D Wang
    • K Raviprakash
    • NU Raja
    • M Luo
    • J Zhang
    • KR Porter
    • JY Dong
  • Combined Therapeutic Use of AdGFPFasL and Small Molecule Inhibitors of Ceramide Metabolism in Prostate and Head and Neck Cancers: A Status Report

    Cancer Gene Therapy, Dec;13(12):1045-51

    Additional authors: Norris K, L. Obeid, Rubinchik S, Tavassoli M, Tomlinson S, Dong J, Voelkel-Johnson C, Liu X.

    Other authors
    • JS Norris
    • A Bielawska
    • T Day
    • A El-Zawahry
    • S Elojeimy
    • Y Hannun
    • M Hyer
    • C Landon
    • S Lowe
    • J McKillop
  • De Novo Syntheses Of Marburg Virus Antigens From Adenovirus Vectors Induce Potent Humoral And Cellular Immune Responses

    Vaccine, 24(15):2975-2986

    Additional authors: Swain BM, Hart MK, Pratt WD, Dong JY.

    Other authors
    • D Wang
    • AL Schmaljohn
    • NU Raja
    • CM Truby
    • LY Juompan
    • M Luo
    • SB Deitz
    • H Yu
    • J Woraratanadharm
    • KM Moore
  • FasL Gene Therapy: A New Therapeutic Modality for Head and Neck Cancer

    Cancer Gene Therapy, Aug;13(8):739-45

    Other authors
    • S Elojeimy
    • JC McKillop
    • AM El-Zawahry
    • X Liu
    • DA Schwartz
    • TA Day
    • JY Dong
    • JS Norris
  • Involvement of sphingolipids in apoptin-induced cell killing

    Molecular Therapy, Nov;14(5):627-36

    Additional authors: Keane TE, Tavassoli M, Hannun YA, Norris JS.

    Other authors
    • X Liu
    • YH Zeidan
    • S Elojeimy
    • AM El-Zawahry
    • GW Guo
    • A Bielawska
    • J Bielawski
    • Z Szulc
    • S Rubinchik
    • JY Dong
  • Modulation of Ceramide Metabolism Enhances Viral Protein Apoptin's Cytotoxicity in Prostate Cancer.

    Molecular Therapy, Nov;14(5):637-46

    Additional authors: Tavassoli M, Norris JS

    Other authors
    • X Liu
    • S Elojeimy
    • AM El-Zawahry
    • A Bielawska
    • J Bielawski
    • S Rubinchik
    • GW Guo
    • JY Dong
    • T Keane
    • YA Hannun
  • New insights on the use of desipramine as an inhibitor for acid ceramidase

    FEBS Letters, Aug 21;580(19):4751-6

    Other authors
    • S Elojeimy
    • X Liu
    • A El-Zawahry
    • M Villani
    • JC Cheng
    • A Mahdy
    • Y Zaidan
    • A Bielawksa
    • YA Hannun
    • JS Norris
  • The present and future for gene and viral therapy of directly accessible prostate and squamous cell cancers of the head and neck

    Future Oncology, 1(1):116-123

    Other authors
    • JS Norris
    • A El-Zawahry
    • TE Keane
    • JY Dong
    • M Tavassoli
  • In vitro efficacy of Fas Ligand gene therapy for the treatment of bladder cancer

    Cancer Gene Therapy, 12(1):12-18

    Other authors
    • S Sudarshan
    • ML Hyer
    • JS Norris
  • Inter partes reviews: the effect of estoppel

    World Intellectual Property Review, Dec. 2015

    Now that the inter partes review system is three years old, what effects have the estoppel provisions had on concurrent or subsequent district court litigation?

    Other authors
    • Eldora Ellison
    See publication

Patents

  • Ceramides and apoptosis-signaling ligand

    Issued US 8,592,419

    The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand.…

    The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.

    Other inventors
    • Alicja Bielawska,
    • Yusuf A. Hannun,
    • James Norris
    • Zdzislaw M. Szulc
    • Jian-Yun Dong
    • Jacek Bielawski
    • David A. Schwartz
    • Ahmed M. El-Zawahry,
    • John McKillop
    See patent

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