Activity
-
On this day in science Etienne-Louis Malus was born He discovered that light waves could be polarised (made to vibrate in a single plane) by…
On this day in science Etienne-Louis Malus was born He discovered that light waves could be polarised (made to vibrate in a single plane) by…
Liked by Evelyn Teran
-
#CellBiology | #Cancer | #Inflammation | Parsing Patterns: Emerging Roles of Tissue Self-Organization in #Health & #Disease | "A DESIGN FOR LIFE" |…
#CellBiology | #Cancer | #Inflammation | Parsing Patterns: Emerging Roles of Tissue Self-Organization in #Health & #Disease | "A DESIGN FOR LIFE" |…
Liked by Evelyn Teran
-
Lung-on-a-chip, Body-on-a-chip, Vagina-on-a-chip... Donald Ingber, the founding director of the Wyss Institute at Harvard University for…
Lung-on-a-chip, Body-on-a-chip, Vagina-on-a-chip... Donald Ingber, the founding director of the Wyss Institute at Harvard University for…
Liked by Evelyn Teran
Experience & Education
Publications
-
Dpr Acts as a Molecular Switch, Inhibiting Wnt Signaling when Unphosphorylated, but Promoting Wnt Signaling when Phosphorylated by Casein Kinase Iδ/ε
PloS ONE
The Wnt pathway is a key regulator of development and tumorigenesis. Dpr (Dact/Frodo) influences Wnt signaling in part through the interaction of its PDZ-B domain with Dsh's PDZ domain. Studies have shown that XDpr1a and its close relative, Frodo, are involved in multiple steps of the Wnt pathway in either inhibitory or activating roles. We found that XDpr1a is phosphorylated by casein kinase Iδ/ε (CKIδ/ε), an activator of Wnt signaling, in the presence of XDsh. Abrogating XDpr1a's ability to…
The Wnt pathway is a key regulator of development and tumorigenesis. Dpr (Dact/Frodo) influences Wnt signaling in part through the interaction of its PDZ-B domain with Dsh's PDZ domain. Studies have shown that XDpr1a and its close relative, Frodo, are involved in multiple steps of the Wnt pathway in either inhibitory or activating roles. We found that XDpr1a is phosphorylated by casein kinase Iδ/ε (CKIδ/ε), an activator of Wnt signaling, in the presence of XDsh. Abrogating XDpr1a's ability to bind XDsh through mutation of XDpr1a's PDZ-B domain blocks CK1δ/ε's phosphorylation of XDpr1a. Conversely, XDsh possessing a mutation in its PDZ domain that is unable to bind XDpr1a does not promote XDpr1a phosphorylation. Phosphorylation of XDpr1a and XDsh by CKIδ/ε decreases their interaction. Moreover, the phosphorylation of XDpr1a by CKIδ/ε not only abrogates XDpr1a's promotion of β-catenin degradation but blocks β-catenin degradation. Our data suggest that XDpr1a phosphorylation by CKIδ/ε is dependent on the interaction of XDpr1a's PDZ-B domain with XDsh's PDZ domain, and that the phosphorylation state of XDpr1a determines whether it inhibits or activates Wnt signaling
Other authors -
More activity by Evelyn
-
The sun was shining and the ideas were flowing at beautiful University of Oxford as we evaluated the advantages of immune synapse formation induced…
The sun was shining and the ideas were flowing at beautiful University of Oxford as we evaluated the advantages of immune synapse formation induced…
Liked by Evelyn Teran
-
Doing an internship during my PhD was a phenomenal opportunity to get a look at what working at Biotech was like, and I also got to work on cool…
Doing an internship during my PhD was a phenomenal opportunity to get a look at what working at Biotech was like, and I also got to work on cool…
Liked by Evelyn Teran
-
It fills me with immense pride and honor to see my sister Lylybell Teran graduate with her Master's in Data Science from an Ivy League school like…
It fills me with immense pride and honor to see my sister Lylybell Teran graduate with her Master's in Data Science from an Ivy League school like…
Shared by Evelyn Teran
Other similar profiles
-
Danielle Klaskin
Senior Research Associate at EvolveImmune Therapeutics
Connect -
Hayden Karp
In Vivo scientist
Connect -
Tiffany Liang
Connect -
Jay Fine
Connect -
Dr. Margarita Narvaez
General Dentist at NYU Dentistry Programs for International Dentists
Connect -
Evelyn Terán
Connect -
Stacey Braun
Owner, Evas's Corner Inc
Connect -
Helena Valla
Cake Decorator at Walmart
Connect -
Eric Chirlin
Connect -
Anne Cepeda
Bilingual Investigator 1 at Office of the Public Defender, NJ
Connect
Explore collaborative articles
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
Explore MoreOthers named Evelyn Teran in United States
-
Evelyn T.
Senior Pastor at Centro Apostolico de Florida Inc.
-
Evelyn Teran
School Psychologist at Livermore Valley Joint Unified School District
-
Evelyn Teran Payano
Manager Renewable Development
-
Evelyn Teran
Logistics and Supply Chain Professional
6 others named Evelyn Teran in United States are on LinkedIn
See others named Evelyn Teran