Alcohol-associated liver disease (#ALD) is a major global health concern, leading to high rates of liver-related morbidity and mortality. A new Consensus Statement by Mack Mitchell, Laura Nagy & colleagues highlights the urgent need for clinical trials to explore effective treatments that integrate approaches for both ALD and alcohol use disorder (#AUD).
The guidelines, published in Nature Reviews Gastroenterology & Hepatology, delve into the complexities of treating ALD alongside AUD, emphasizing the importance of combining methodologies from both fields to enhance the quality and effectiveness of clinical trials. After an extensive literature search and discussion of expert opinion, 28 recommendations for clinical trials of alcohol use and ALD were developed, with recommendations related to definitions of alcohol use, minimum data sets, statistical considerations and more.
READ HERE: https://lnkd.in/eBVa_p3M
An accompanying News & Views by Juliana Serrazine & Helena Cortez-Pinto puts these new recommendations into context and discuss how the new guidelines offer a structured framework for conducting research in this field, which should hopefully facilitate development of novel therapies.
READ HERE: https://rdcu.be/dKNhq
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Daniel Quirk, MD, MPH, MBA Bristol Myers Squibb This is phenomenal. Great work!!