Epidemiology of leukemia in children with Down syndrome
- PMID: 15390275
- DOI: 10.1002/pbc.20165
Epidemiology of leukemia in children with Down syndrome
Abstract
Studies suggest nearly a 20-fold increased risk of leukemia in individuals with Down syndrome. Most of this increased risk appears in the first few decades of life, with the highest incidence in children less than 5 years of age. It is unknown why children with Down syndrome are at such an increased risk of leukemia. With respect to environmental exposures, it will be important to investigate risk factors associated with childhood leukemia in general (including diagnostic x-rays, pesticides, and other occupational exposures) as well as experiences common to children with Down syndrome (including routine medical screening tests, increased susceptibility to infections, and increased vitamin deficiencies).
(c) 2004 Wiley-Liss, Inc.
Similar articles
-
Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.Cancer Epidemiol Biomarkers Prev. 2015 Feb;24(2):454-8. doi: 10.1158/1055-9965.EPI-14-1181. Epub 2014 Dec 10. Cancer Epidemiol Biomarkers Prev. 2015. PMID: 25499068 Free PMC article.
-
Epidemiology of childhood leukemia in the presence and absence of Down syndrome.Cancer Epidemiol. 2014 Oct;38(5):479-89. doi: 10.1016/j.canep.2014.07.006. Epub 2014 Aug 10. Cancer Epidemiol. 2014. PMID: 25113940 Review.
-
Cancer incidence of persons with Down syndrome in Finland: a population-based study.Int J Cancer. 2006 Apr 1;118(7):1769-72. doi: 10.1002/ijc.21518. Int J Cancer. 2006. PMID: 16231334
-
Periconceptional vitamin useand leukemia risk in children with Down syndrome: a Children's Oncology Group study.Cancer. 2005 Jul 15;104(2):405-10. doi: 10.1002/cncr.21171. Cancer. 2005. PMID: 15952191
-
[Epidemiology of leukemias in children].Arkh Patol. 1997 Sep-Oct;59(5):65-70. Arkh Patol. 1997. PMID: 9446542 Review. Russian.
Cited by
-
Cancer risks related to intellectual disabilities: A systematic review.Cancer Med. 2024 May;13(9):e7210. doi: 10.1002/cam4.7210. Cancer Med. 2024. PMID: 38686623 Free PMC article. Review.
-
Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Int J Mol Sci. 2023 Oct 18;24(20):15325. doi: 10.3390/ijms242015325. Int J Mol Sci. 2023. PMID: 37895004 Free PMC article.
-
Transcriptomic analysis of stem cells from chorionic villi uncovers the impact of chromosomes 2, 6 and 22 in the clinical manifestations of Down syndrome.Stem Cell Res Ther. 2023 Sep 23;14(1):265. doi: 10.1186/s13287-023-03503-4. Stem Cell Res Ther. 2023. PMID: 37740230 Free PMC article.
-
Medical imaging utilization and associated radiation exposure in children with down syndrome.PLoS One. 2023 Sep 6;18(9):e0289957. doi: 10.1371/journal.pone.0289957. eCollection 2023. PLoS One. 2023. PMID: 37672503 Free PMC article.
-
Heart Transplantation in Children With Down Syndrome.J Am Heart Assoc. 2022 May 17;11(10):e024883. doi: 10.1161/JAHA.121.024883. Epub 2022 May 16. J Am Heart Assoc. 2022. PMID: 35574952 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical