Preeclampsia, pregnancy-related hypertension, and breast cancer risk
- PMID: 17284721
- DOI: 10.1093/aje/kwk105
Preeclampsia, pregnancy-related hypertension, and breast cancer risk
Abstract
Pregnancy conditions accompanied by high blood pressure, such as preeclampsia and pregnancy-related hypertension, have been associated with a lower risk of breast cancer in several epidemiologic studies. It is unknown whether length of gestation or multiple occurrence of these conditions alters the association with breast cancer. It is also unknown whether the inverse association between preeclampsia and breast cancer risk is modified by menopausal status at breast cancer diagnosis. Using data from a large, population-based case-control study of breast cancer conducted on Long Island, New York, during 1996-1997, the authors examined these questions among ever-parous women (1,310 cases and 1,385 controls) using multivariate logistic models. Preeclampsia was inversely associated with breast cancer (odds ratio = 0.7, 95% confidence interval: 0.5, 1.0); this association was even stronger among women who had multiple occurrences of preeclampsia (odds ratio = 0.3, 95% confidence interval: 0.1, 0.9). The risk reduction was more pronounced among postmenopausal women. Gestation length did not substantially alter the relation between preeclampsia and breast cancer risk. Pregnancy-related hypertension was also inversely associated with breast cancer risk, but the relations were not statistically significant after adjustment for preeclampsia. These data suggest that pregnancy conditions related to hypertension, particularly preeclampsia, play a role in reducing breast cancer risk. Possible biologic mechanisms underpinning these associations should be further explored.
Similar articles
-
Normal and high-normal blood pressures, but not body mass index, are risk factors for the subsequent occurrence of both preeclampsia and gestational hypertension: a retrospective cohort study.Hypertens Res. 2006 Mar;29(3):161-7. doi: 10.1291/hypres.29.161. Hypertens Res. 2006. PMID: 16755151
-
Migraine headaches and preeclampsia: an epidemiologic review.Headache. 2006 May;46(5):794-803. doi: 10.1111/j.1526-4610.2006.00432.x. Headache. 2006. PMID: 16643583 Review.
-
Mean arterial pressure, pregnancy-induced hypertension, and preeclampsia: evaluation as independent risk factors and as surrogates for high maternal serum alpha-fetoprotein in estimating breast cancer risk.Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1349-55. Cancer Epidemiol Biomarkers Prev. 2000. PMID: 11142421
-
Preeclampsia and breast cancer risk.Epidemiology. 1999 Nov;10(6):722-32. Epidemiology. 1999. PMID: 10535787 Review.
-
Characteristics of first pregnancy in relation to early breast cancer. A case-control study.J Reprod Med. 1983 May;28(5):314-8. J Reprod Med. 1983. PMID: 6152984
Cited by
-
Causal effects of hypertensive disorders of pregnancy on future gynecologic tumors: A two-sample Mendelian randomization study.Cancer Med. 2024 May;13(10):e7300. doi: 10.1002/cam4.7300. Cancer Med. 2024. PMID: 38800978 Free PMC article.
-
A common IGF1R gene variant predicts later life breast cancer risk in women with preeclampsia.Breast Cancer Res Treat. 2023 Jan;197(1):149-159. doi: 10.1007/s10549-022-06789-9. Epub 2022 Nov 4. Breast Cancer Res Treat. 2023. PMID: 36331687 Free PMC article.
-
Hypertensive diseases of pregnancy and risk of breast cancer in the Black Women's Health Study.Breast Cancer Res Treat. 2022 Jul;194(1):127-135. doi: 10.1007/s10549-022-06606-3. Epub 2022 Apr 28. Breast Cancer Res Treat. 2022. PMID: 35478297 Free PMC article.
-
Hypertensive Disorders of Pregnancy (HDP) and the Risk of Common Cancers in Women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk Prospective Population-Based Study.Cancers (Basel). 2020 Oct 23;12(11):3100. doi: 10.3390/cancers12113100. Cancers (Basel). 2020. PMID: 33114193 Free PMC article.
-
Investigation of the association between metabolic syndrome and breast cancer patients.Eur J Transl Myol. 2020 Apr 1;30(1):8776. doi: 10.4081/ejtm.2019.8776. eCollection 2020 Apr 7. Eur J Transl Myol. 2020. PMID: 32499883 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical