Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies
- PMID: 17505075
- DOI: 10.1093/jnci/djk181
Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies
Abstract
Background: The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases.
Methods: We performed a pooled analysis of 12 prospective studies that included 530,469 women and 229,575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided.
Results: A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100,000 person-years among nondrinkers and 15 per 100,000 person-years among those who drank 15 g/day or more of alcohol. Compared with nondrinking, alcohol consumption (> or = 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P(trend)<.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (P(heterogeneity) = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40).
Conclusion: Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.
Similar articles
-
Alcohol intake and the risk of chronic kidney disease: results from a systematic review and dose-response meta-analysis.Eur J Clin Nutr. 2021 Nov;75(11):1555-1567. doi: 10.1038/s41430-021-00873-x. Epub 2021 Mar 5. Eur J Clin Nutr. 2021. PMID: 33674776 Review.
-
A meta-analysis of alcohol consumption and thyroid cancer risk.Oncotarget. 2016 Aug 23;7(34):55912-55923. doi: 10.18632/oncotarget.10352. Oncotarget. 2016. PMID: 27385005 Free PMC article. Review.
-
Total fluid intake and use of individual beverages and risk of renal cell cancer in two large cohorts.Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1204-11. doi: 10.1158/1055-9965.EPI-05-0889. Cancer Epidemiol Biomarkers Prev. 2006. PMID: 16775182
-
Alcohol consumption and risk of renal cell carcinoma: a prospective study of Swedish women.Int J Cancer. 2005 Dec 10;117(5):848-53. doi: 10.1002/ijc.21231. Int J Cancer. 2005. PMID: 15957170
-
Intake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin.Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):1119-22. Cancer Epidemiol Biomarkers Prev. 2002. PMID: 12376519
Cited by
-
Early-onset and later-onset cancer: trends, risk factors, and prevention in Northern China.Sci China Life Sci. 2024 May 23. doi: 10.1007/s11427-023-2523-5. Online ahead of print. Sci China Life Sci. 2024. PMID: 38809499
-
Effect of smoking, hypertension and lifestyle factors on kidney cancer - perspectives for prevention and screening programmes.Nat Rev Urol. 2023 Nov;20(11):669-681. doi: 10.1038/s41585-023-00781-8. Epub 2023 Jun 16. Nat Rev Urol. 2023. PMID: 37328546 Review.
-
The association of healthy lifestyle index score and the risk of renal cell cancer in the Netherlands cohort study.BMC Cancer. 2023 Feb 16;23(1):156. doi: 10.1186/s12885-023-10627-6. BMC Cancer. 2023. PMID: 36797692 Free PMC article.
-
Understanding the link between kidney stones and cancers of the upper urinary tract and bladder.Am J Clin Exp Urol. 2022 Oct 15;10(5):277-298. eCollection 2022. Am J Clin Exp Urol. 2022. PMID: 36313208 Free PMC article. Review.
-
Alcohol and Health Outcomes: An Umbrella Review of Meta-Analyses Base on Prospective Cohort Studies.Front Public Health. 2022 May 4;10:859947. doi: 10.3389/fpubh.2022.859947. eCollection 2022. Front Public Health. 2022. PMID: 35602135 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical