Alcohol consumption and risk of hematological malignancies: A meta-analysis of prospective studies
- PMID: 29460427
- DOI: 10.1002/ijc.31330
Alcohol consumption and risk of hematological malignancies: A meta-analysis of prospective studies
Abstract
Current convincing evidence suggests that alcohol intake increases the risk of several carcinomas, which might subsequently lead to a recommendation toward limiting alcohol consumption. However, there are accumulating data worth meta-analyzing that show a different effect on the risk of hematological malignancies. Eligible cohort studies were sought in PubMed database up to August 31, 2016. Separate analyses were performed by subtype of hematological malignancy (non-Hodgkin lymphoma [NHL] and subtypes, Hodgkin lymphoma [HL], leukemia and subtypes), time status (ever, current, former), level of consumption (light, moderate, heavy), alcoholic beverage (total alcohol, beer, liquor, wine) and gender. Moderate and heavy alcohol consumption were significantly associated with reduced risk of NHL (relative risk [RR] = 0.85, 95% confidence interval [CI]: 0.80-0.90 and RR = 0.73, 95%CI: 0.60-0.89, respectively); a protective trend was also shown for light alcohol intake (RR = 0.93, 95%CI: 0.87-1.00). Specifically, beer consumption was associated with reduced NHL risk (RR = 0.88, 95%CI: 0.81-0.95). However, the association regarding other alcoholic beverages seemed null. The beneficial effects of alcohol mainly pertained to Diffuse Large B-Cell Lymphoma (DLBCL) (RR = 0.83, 95%CI: 0.77-0.89) and Follicular Lymphoma (FL) (RR = 0.85, 95%CI: 0.78-0.93). There was also no association between alcohol consumption and risk of HL or leukemias. In contrast to most solid malignancies, alcohol seems to confer a protective effect on NHL risk, especially on DLBCL and FL subtypes, with beer being notably beneficial.
Keywords: Hodgkin lymphoma; alcohol; leukemia; meta-analysis; non-Hodgkin lymphoma.
© 2018 UICC.
Similar articles
-
Anthropometric characteristics, physical activity and risk of hematological malignancies: A systematic review and meta-analysis of cohort studies.Int J Cancer. 2019 Jul 15;145(2):347-359. doi: 10.1002/ijc.32109. Epub 2019 Feb 12. Int J Cancer. 2019. PMID: 30614529
-
Consumption of fruits, vegetables, and risk of hematological malignancies: a systematic review and meta-analysis of prospective studies.Leuk Lymphoma. 2018 Feb;59(2):434-447. doi: 10.1080/10428194.2017.1339873. Epub 2017 Aug 28. Leuk Lymphoma. 2018. PMID: 28847196 Review.
-
Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis.Eur J Cancer Prev. 2017 Sep;26(5):433-441. doi: 10.1097/CEJ.0000000000000350. Eur J Cancer Prev. 2017. PMID: 28379884 Review.
-
Alcohol intake, alcoholic beverage type and multiple myeloma risk: a meta-analysis of 26 observational studies.Leuk Lymphoma. 2015 May;56(5):1484-501. doi: 10.3109/10428194.2014.956312. Epub 2014 Nov 20. Leuk Lymphoma. 2015. PMID: 25146435
-
Alcohol consumption and risk of hematologic malignancies.Ann Epidemiol. 2009 Oct;19(10):746-53. doi: 10.1016/j.annepidem.2009.03.005. Epub 2009 Apr 25. Ann Epidemiol. 2009. PMID: 19394864
Cited by
-
Causal relationship between circulating cytokines and follicular lymphoma: a two-sample Mendelian randomization study.Am J Cancer Res. 2024 Apr 15;14(4):1577-1593. doi: 10.62347/JCKD6973. eCollection 2024. Am J Cancer Res. 2024. PMID: 38726270 Free PMC article.
-
Alcohol and Health Outcomes: An Umbrella Review of Meta-Analyses Base on Prospective Cohort Studies.Front Public Health. 2022 May 4;10:859947. doi: 10.3389/fpubh.2022.859947. eCollection 2022. Front Public Health. 2022. PMID: 35602135 Free PMC article.
-
Alcohol, Drinking Pattern, and Chronic Disease.Nutrients. 2022 May 7;14(9):1954. doi: 10.3390/nu14091954. Nutrients. 2022. PMID: 35565924 Free PMC article. Review.
-
Metabolic Disorders in Multiple Myeloma.Int J Mol Sci. 2021 Oct 22;22(21):11430. doi: 10.3390/ijms222111430. Int J Mol Sci. 2021. PMID: 34768861 Free PMC article. Review.
-
Three Primary Cancers in a Veteran With Agent Orange and Agent Blue Exposures.Fed Pract. 2021 Aug;38(Suppl 3):S40-S45. doi: 10.12788/fp.0161. Fed Pract. 2021. PMID: 34733094 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical